| 发明名称 |
CONFORMATIONALLY RESTRAINED PEPTIDE ANALOGS AS ANTIPLATELET AGENTS. |
| 摘要 |
<p>The present invention relates to cyclic peptide analogs containing a pseudo-bond, useful as platelet aggregation inhibitors. An example of a compound of this invention includes Cyclo[Ala PSI [CH2NH]-Arg-Gly-Asp- delta -Glu](NHBn).CF3CO2H. These compounds inhibit the binding of fibrinogen to the platelet GPIIb-IIIa integrin receptor which inhibits platelet aggregation and therefore these compounds act as potent antithrombotics.</p> |
| 申请公布号 |
GR3027738(T3) |
申请公布日期 |
1998.11.30 |
| 申请号 |
GR19980401921T |
申请日期 |
1998.08.26 |
| 申请人 |
MERRELL DOW PHARMACEUTICALS INC. |
发明人 |
HARBESON, SCOTT, L.;BITONTI, ALAN, J. |
| 分类号 |
A61K38/00;A61P7/02;C07K5/02;C07K5/06;C07K5/08;C07K5/083;C07K5/093;C07K5/10;C07K5/103;C07K5/113;C07K7/02;C07K7/06;C07K7/56;C07K14/75;(IPC1-7):C07K5/06 |
主分类号 |
A61K38/00 |
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