METHOD OF CELL FRACTIONATION AND SUBSTRATE TO BE USED FOR THE METHOD

摘要

In a method of cell fractionation according to the invention, by using a ligand-presenting substrate in which a ligand capable of temporarily binding to a receptor present on the surface of a cell desired to be fractionated is immobilized via a graft chain, cells are rotationally transferred on the surface of the ligand-presenting substrate and a difference in the transfer rate caused by the binding degree is utilized. This achieves a method of fractionating a cell presenting a specific receptor on the cell surface from a group of cells including the cell, in which the cell having a receptor density within a predetermined range can be fractionated efficiently and highly accurately and the cells having respective densities can be continuously fractionated from the group of cells depending on the receptor density.