发明名称 |
CD40 LIGAND FUSION PROTEIN VACCINE |
摘要 |
Provided are methods of generating an immune response to any of various antigens including foreign antigens such as infectious agent antigens. In general, the method comprises administering an expression vector encoding a transcription unit encoding a secretable fusion protein, the fusion protein containing the foreign antigen and CD40 ligand and also administering the encoded fusion protein. In another approach, an immune response to the foreign antigen is elicited using the encoded fusion protein without administering the vector. The invention methods may be used to immunize an individual against an infectious agent such as influenza virus. Methods of obtaining an immune response in older individuals also is described. |
申请公布号 |
WO2007056266(A2) |
申请公布日期 |
2007.05.18 |
申请号 |
WO2006US43164 |
申请日期 |
2006.11.06 |
申请人 |
SIDNEY KIMMEL CANCER CENTER;TANG, YUCHENG;DEISSEROTH, ALBERT |
发明人 |
TANG, YUCHENG;DEISSEROTH, ALBERT |
分类号 |
A61K39/145;A61K48/00 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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