IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS COMPRISING MODIFIED IMMUNOSTIMULATORY DINUCLEOTIDES

摘要

The invention relates to the therapeutic use of oligonucleotides as
immunostimulatory agents in immunotherapy applications. More particularly, the
invention provides an immunostimulatory oligonucleotides for use in methods
for generating an immune response or for treating a patient in need of
immunostimulation. The immunostimulatory oligonucleotides of the invention
preferably comprise novel purines. The immunostimulatory oligonucleotides
according to the invention further comprise at least two oligonucleotides
linked at their 3'' ends, intemucleoside linkages or functionalized nucleobase
or sugar to a non-nucleotidic linker, at least one of the oligonucleotides
being an immunostimulatory oligonucleotide and having an accessible 5'' end.