Preparation of aromatic nitrile by catalytic cyanation of aromatics in an inert organic solvent in the presence of chlorocyanine and Lewis acid and reconditioning the obtained cyclic compound e.g. 4,6,8-trimethyl-azulene-1-carbonitrile

摘要

Preparation of aromatic nitrile by catalytic cyanation of aromatics in the presence of organic solvents, comprises reacting a heterocyclic compound (a) or (b), or a phenyl compound (c) or (d), 4,6,8-trimethyl-azulene in an inert organic solvent with chlorocyanine in the presence of Lewis acid, at 0-160[deg]C; and reconditioning the obtained cyclopentadiene-cyanide compound (a1), (b1) or (b2), phenyl-cyanide compound (c1), (c2), (d1) or (d2), 4,6,8-trimethyl-azulene-1-carbonitrile or 4,6,8-trimethyl-azulene-1,3-dicarbonitrile. Preparation of aromatic nitrile by catalytic cyanation of aromatics in the presence of organic solvents, comprises reacting a heterocyclic compound of formula (a) or (b), or a phenyl compound of formula (c) or (d), 4,6,8-trimethyl-azulene in an inert organic solvent with chlorocyanine in the presence of Lewis acid, at 0-160[deg]C; and reconditioning the obtained cyclopentadiene-cyanide compound of formula (a1), (b1) or (b2), phenyl-cyanide compound of formula (c1), (c2), (d1) or (d2), 4,6,8-trimethyl-azulene-1-carbonitrile or 4,6,8-trimethyl-azulene-1,3-dicarbonitrile. R1>S, NH or O; R2>SRa, ORb, NRbRc or substituted phenyl; Ra, Rb, Rc : H, optionally substituted phenyl or 1-6C alkyl; and D : -CH=CH-CH=CH-, -CH=CH-CH2- or -CH=CH-R1>-. [Image] [Image] [Image].