发明名称 |
GENE CODING FOR D40, CASC5 OR SPLICING ISOFORM PROTEIN OF CANCER-TESTIS ANTIGEN PROTEIN, METHOD FOR INDUCING PREVENTION OF PROLIFERATION/MITOSIS OF CANCER CELL AND DEATH OF CELL BY BRINGING THE GENE PRODUCT AS TARGET AND METHOD FOR SCREEING MATERIAL FOR INDUCING PREVENTION OF THE PROLIFERATION/MITOSIS AND DEATH OF THE CELL |
摘要 |
PROBLEM TO BE SOLVED: To provide a method for inducing prevention of proliferation/mitosis and/or death of cells of cancer cells, an inducer for preventing selective proliferation/mitosis and/or death of the cancer cells used in the method and a method for screening a therapeutic and/or preventive agent for the cancer. SOLUTION: The prevention of proliferation/mitosis and/or death of the cancer cells is induced by suppressing expression of gene coding for the cancer-testis antigen protein D40 or CASC5 in the cancer cells or the splicing isoform protein of the cancer-testis antigen protein. The screening of a material for inducing the prevention of proliferation/mitosis and/or death of cells of the cancer cells or a therapeutic/preventive agent for the cancer is performed by using the splicing isoform protein of the cancer-testis antigen protein as a target. The RNA interference method by dsRNA is used for suppressing expression of the cancer-testis antigen protein gene. COPYRIGHT: (C)2007,JPO&INPIT
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申请公布号 |
JP2007112724(A) |
申请公布日期 |
2007.05.10 |
申请号 |
JP20050303676 |
申请日期 |
2005.10.18 |
申请人 |
HOKKAIDO UNIV |
发明人 |
TAKIMOTO MASAHITO;YURI URATA;KUZUMAKI SUSUMU |
分类号 |
A61K45/00;A61K31/713;A61K48/00;A61P35/00;A61P43/00;C12N15/09;C12Q1/02;G01N33/15;G01N33/50 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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地址 |
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