发明名称 |
INHIBITION OF AUTOPHAGY GENES IN CANCER CHEMOTHERAPY |
摘要 |
<p>There is provided compositions and methods for improving the therapeutic efficacy of various cancer treatments, for example endocrine therapy, chemotherapy or radiation therapy, by inhibiting the expression of one or more genes involved in the cellular autophagy response. The compositions include compositions comprising an siRNA directed against an Atg gene and may be used to inhibit expression of an Atg gene in a cell currently undergoing cancer therapy, or to treat, inhibit or prevent cancer in a subject in combination with a cancer therapy.</p> |
申请公布号 |
WO2007051316(A1) |
申请公布日期 |
2007.05.10 |
申请号 |
WO2006CA01822 |
申请日期 |
2006.11.03 |
申请人 |
BRITISH COLUMBIA CANCER AGENCY;GORSKI, SHARON, MARGARET;QADIR, MOHAMMAD, ABDUL |
发明人 |
GORSKI, SHARON, MARGARET;QADIR, MOHAMMAD, ABDUL |
分类号 |
A61K48/00;A61K31/7088;A61K31/713;A61K38/43;A61K39/395;A61P35/00;C07H21/02;C12N15/11;C12N15/113;C12N15/12 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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