EFFICACY OF CALCIMIMETIC AGENTS

摘要

A method of assessing the efficacy of a calcimimetic drug to treat hyperparathyroidism in a subject may include determining which alleles for a calcium-sensitive receptor (CaSR) gene the subject carries; and concluding that the calcimimetic drug will have a first or highest efficacy if the subject has a ⁹⁹⁰Gly-⁹⁹⁰Gly genotype, a second or intermediate efficacy if the subject has a ⁹⁹⁰Gly-⁹⁹⁰Arg genotype, or a third or lowest efficacy if the subject has a ⁹⁹⁰Arg-⁹⁹⁰Arg genotype. In one embodiment, the calcimimetic drug may be cinacalcet or any pharmaceutically acceptable salt thereof.