IMPROVING THE PHARMACOKINETICS OF PROTEASE INHIBITORS AND OTHER DRUGS
摘要
<p>A method for modulating at least one pharmacokinetic property of a protease inhibitor upon administration to a host is provided. One administers to the host an effective amount of a bifunctional compound of less than about 5000 daltons comprising the protease inhibitor or an active derivative thereof and a pharmacokinetic modulating moiety. The pharmacokinetic modulating moiety binds to at least one intracellular protein. The bifunctional compound has at least one modulated pharmacokinetic property upon administration to the host as compared to a free drug control that comprises the protease inhibitor.</p>
申请公布号
WO2007053792(A2)
申请公布日期
2007.05.10
申请号
WO2006US43400
申请日期
2006.11.06
申请人
AMPLYX PHARMACEUTICALS, INC.;MUTZ, MITCHELL, W.;GESTWICKI, JASON, E.