Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1 -medicated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.
申请公布号
WO2007002667(A3)
申请公布日期
2007.05.10
申请号
WO2006US24969
申请日期
2006.06.22
申请人
CHEMOCENTRYX, INC.;ZHANG, PENGLIE;PENNELL, ANDREW, M.K.;WRIGHT, JOHN J. KIM;CHEN, WEI;LELETI, MANMOHAN, R.;RONSHEIM, MATTHEW
发明人
ZHANG, PENGLIE;PENNELL, ANDREW, M.K.;WRIGHT, JOHN J. KIM;CHEN, WEI;LELETI, MANMOHAN, R.;RONSHEIM, MATTHEW