Preparation of 2-(7-chloro-1,8-napthyridine-2-yl)-3-(5-methyl-2-oxo-hexyl)-1-isindolinone, or pagoclone - a GABA receptor ligand

摘要

A method of making racemic 2-(7-chloro-1,8-naphthyridin-2-yI)-3-(5- methyl-2-oxohexyl)-1-isoindolinone is disclosed, the method comprises the step of reacting hydroxyindolinone of formula (4) with a 5-methyl-2-oxo-hexyl triphenylphosphonium halide to form racemic 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone which may be further resolved to provide (+)-2-(7-chloro-1,8-naphthyridin-2-yI)-3-(5- methyl-2-oxohexyl)-1-isoindolinone.