BENZAMIDE COMPOUNDS USEFUL AS HISTONE DEACETYLASE INHIBITORS

摘要

The invention concerns benzamide compounds of formula (I), wherein R<SUP>1</SUP> is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C<SUB>1-4</SUB>alkyl, C<SUB>3-4</SUB>cycloalkyl, C<SUB>1-4</SUB>alkoxy and C<SUB>3-4 </SUB>cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC).