The present invention provides novel self-replicating and self-propagating chimeric viral vectors and chimeric virus particles comprising a modified genome of a carrier RNA virus packaged within structural proteins of a second virus. Also provided are pharmaceutical formulations comprising the chimeric viral vectors and virus particles and methods of inducing an immune response by administration of the same to a subject.
申请公布号
WO2007046839(A2)
申请公布日期
2007.04.26
申请号
WO2006US05338
申请日期
2006.02.15
申请人
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;CHILDREN'S HOSPITAL, INC.;JOHNSTON, ROBERT, E.;JOHNSON, PHILIP, R.