| 摘要 |
The invention concerns compounds of formula (I), wherein: R1 represents a hydroxy group or a RCO-O- group; R2 represents a hydrogen, halogen atom, a hydroxy group or a R'CO-O group; R, R', identical or different, represent an optionally substituted alkyl group; R3 represents a hydrogen atom, an alkyl group or a cycloalkyl group; A represents a CR4R5 group or a NR4 group; R4 represents a hydrogen atom or an alkyl group; their isomers and their addition salts to a pharmaceutically acceptable acid or base. Said compounds are useful as AMPA modulators for treating or preventing memory and learning disorders associated with age, anxiety or depression syndromes, gradual neurodegenerative diseases,Alzheimer's disease, Pick's disease, Huntington's chorea, schizophrenia, sequels of acute neurodegenerative diseases, ischemia sequels and epilepsy sequels. , (I)
|
