发明名称 |
Anticuerpo monoclonal anti-ADDL y usos del mismo |
摘要 |
The present invention relates to antibodies that bind amyloid &bgr;-derived diffusible ligands, also known as ADDLs. The antibodies of the invention are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs. |
申请公布号 |
ES2573135(T3) |
申请公布日期 |
2016.06.06 |
申请号 |
ES20110807457T |
申请日期 |
2011.07.13 |
申请人 |
Merck Sharp & Dohme Corp. |
发明人 |
GASPAR, Renee C.;SHUGHRUE, Paul J.;WANG, Fubao;WANG, Weirong;ZHANG, Ningyan;ZHAO, Wei-Qin;McCAMPBELL, Alexander;XU, Min |
分类号 |
C07K16/18;A61K39/395;A61P25/28 |
主分类号 |
C07K16/18 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|