Methods for the production and cytotocity evaluation of KIR2DL NK-receptor antibodies
摘要
The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly in therapy, to increase NK cell activity or cytotoxicity in subjects.
申请公布号
ZA200600792(B)
申请公布日期
2007.04.25
申请号
ZA20060000792
申请日期
2006.01.27
申请人
NOVO NORDISK A/A;INNATE PHARMA S.A.S.;UNIVERSITY OF GENOA
发明人
PADKJAER, SOEREN BERG;MORETTA, ALESSANDRO;CHIESA, MARIELLA DELLA;ANDRE, PASCALE;GAUTHIER, LAURENT;WAGTMANN, PETER ANDREAS NICOLAI REUMERT