CYCLIC PEPTIDES THAT BIND TO UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR

摘要

Cyclic peptide compounds having 11 amino acids joined by a linking unit (L), such that the linear dimension between the C.alpha. carbon of the first amino acid and the C.alpha. carbon of eleventh amino acid is between about 4 and 12 .ANG.ngstrom units; are useful for inhibiting the binding of .mu.PA to the .mu.PAR receptor. Methods for using the cyclic peptide compounds, and compositions containing them, for inhibiting the growth or metastasis of cancerous tumors are also disclosed.