| 摘要 |
A method of stimulating in vivo or ex vivo maturation of dendritic cells by applying an effective amount of inosine-containing compounds to the dendritic cells. The maturation of dendritic cells leads to more robust cellular immune responses against antigens including those associated with vaccines, infectious agents, and tumor cells by enhancing the stimulatory activity of dendritic cells toward T cells. An in vivo or ex vivo method of treating diseases in a subject by applying an effective amount of an inosine-containing compound to the dendritic cells to stimulate maturation thereof; and administering matured dendritic cells into the subject. A method of enhancing the immune response of a host mammal by isolating immature dendritic cells from a donor mammal; maturing the immature dendritic cells in the presence of an inosine-containing compound ex vivo; and administering the mature dendritic cells to a host mammal in an amount effective to enhance the immune response of the host mammal. A method of maturing dendritic cells in vivo or ex vivo in the presence of an inosine-containing compound, which results in increasing the stimulation of T cells in response to an antigen. A method of enhancing the immunological response to vaccine antigens by inclusion of an inosine-containing compound. A composition for in vivo or ex vivo maturation of dendritic cells including an inosine-containing compound, wherein one possible form of the inosine-containing compound is an IpR oligonucleotide molecule. Compositions, pharmaceutical composition, adjuvants, immunostimulants, and kits for maturing dendritic cells in vivo or ex vivo including an inosine-containing compound.
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