The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that a signal intensity is produced for each of the probes; computationally identifying optimized probes which exhibit signal intensities that correspond to the serial dilutions of genomic sample and are reproducibly strong relative to non-optimized probes.
申请公布号
WO2006084216(A3)
申请公布日期
2007.04.12
申请号
WO2006US04017
申请日期
2006.02.03
申请人
NIMBLEGEN SYSTEMS, INC.;RICHMOND, TODD;NORTON, JASON;NUWAYSIR, EMILE, F.;GREEN, ROLAND;NUWAYSIR, KATE
发明人
RICHMOND, TODD;NORTON, JASON;NUWAYSIR, EMILE, F.;GREEN, ROLAND;NUWAYSIR, KATE