METHOD OF DIAGNOSIS OF TUBERCULOSIS RELATED IMMUNE RESTORATION SYNDROME (IRS)

摘要

The present invention relates to a method and kit of diagnosis of Immune Restoration Syndrome associated with tuberculosis (TB-IRS) in patients infected with tuberculosis (TB) as well as in HIV co-infected patients comprising detecting an acute increase in Th1 response following exposure to mycobacterial extract, referred as tuberculin or PPD (Purified Protein Derivative) as well as to the 16kDa protein, but not to ESAT-6 or CFP-10, two antigens from mycobacterium tuberculosis.