| 摘要 |
It is intended to provide a novel quinazoline derivative with less skin irritancy and an excellent action of strongly suppressing scratching behavior and a pharmaceutical composition containing the quinazoline derivative as an active ingredient. The invention is directed to the quinazoline derivative represented by the general formula [1] or a pharmaceutically acceptable salt thereof. R1 represents hydrogen or the like, R2 represents hydrogen or the like, R3 and R4 are the same or different and represent hydrogen, alkyl, alkoxy or halogen, R5 represents alkylene together with R6 or represents hydrogen, hydroxy, alkyl, phenyl or alkoxy, R6 represents (1) alkyl, (2) cycloalkyl, (3) phenyl, (4) a 5- to 10-membered aromatic heterocyclic group with 1 to 3 heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or (5) -N(R61)(R62).
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