Gene differentially expressed in breast and bladder cancer, and encoded polypeptides

摘要

The present invention is directed to antibodies or antigen binding fragments thereof that specifically bind to the cancer specific antigen, C35. This invention also relates to a polynucleotide encoding the antibody or antigen binding fragment thereof as well as vectors and host cells comprising the polynucleotide. The present invention further relates to a composition comprising the antibody or antigen binding fragment thereof or further comprising a chemotherapeutic agent, specifically taxol. The invention is also directed to therapeutic and diagnostic methods of using antibodies against C35, preferably more than one anti-C35 antibody in combination with a chemotherapeutic agent, to treat C35 associated cancer.