发明名称 |
METHOD AND ANTISENSE COMPOUND FOR POTENTIATING ANTI-CANCER AGENTS |
摘要 |
A method and compound for enhancing the lethality of an anti-cancer therapy, such as radiation, chemotherapy, or TRAIL protein, are disclosed. The compound is composed of morpholino subunits joined by phosphorodiamidate linkages, and has a targeting sequence that is complementary to an AUG start, IRES, or splice-donor region of the transcript for human X-linked inhibitor of apoptosis protein (XIAP). The method includes exposing cancer cells to the compound. |
申请公布号 |
WO2005047465(A3) |
申请公布日期 |
2007.04.12 |
申请号 |
WO2004US36851 |
申请日期 |
2004.11.05 |
申请人 |
AVI BIOPHARMA, INC.;DEVI, GAYATHRI, R.;IVERSEN, PATRICK, L. |
发明人 |
DEVI, GAYATHRI, R.;IVERSEN, PATRICK, L. |
分类号 |
A61K48/00;A61K31/675;C07F9/6533;C07H21/04;C12N |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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