| 发明名称 |
Method for the synthesis of BCH-189 (2',3'-dideoxy-3'-thia-cytidine) |
| 摘要 |
<p>The present invention relates to a method of preparing BCH-189 and various analogues of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation of the biologically active isomer of these compounds, ²-BCH-189 and related compounds. Furthermore, the stereochemistry at the nucleoside 4'-position can be controlled to produce enantiomerically-enriched ²-BCH-189 and its analogues.</p> |
| 申请公布号 |
EP1772151(A2) |
申请公布日期 |
2007.04.11 |
| 申请号 |
EP20060077328 |
申请日期 |
1991.01.31 |
| 申请人 |
EMORY UNIVERSITY |
发明人 |
LIOTTA, DENNIS C.;CHOI, WOO-BAEG;SCHINAZI, RAYMOND F. |
| 分类号 |
A61K31/505;A61K;A61K31/00;A61K31/39;A61K31/513;A61K31/695;A61K31/7064;A61K31/7068;A61P31/12;A61P31/18;C07D;C07D239/02;C07D327/04;C07D405/04;C07D411/04;C07D451/00;C07F7/18;C07H19/06;C07H19/10;C12P19/38;C12P41/00 |
主分类号 |
A61K31/505 |
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