摘要 |
The present application provides a human gene over-expressing animal, which is a non-human animal carrying a human hematopoietic prostaglandin D<SUB>2 </SUB>synthase gene in its somatic cell chromosome and expressing a large amount of human prostaglandin D<SUB>2 </SUB>synthase, wherein the animal is one obtained through ontogenesis of a totipotency cell of a non-human animal or offspring of the obtained animal, and the totipotency cell is introduced with said synthase gene. The present application also provides a method of using the transgenic animal for testing in vivo activity of a candidate for anti-allergy medicines, sleep-controlling substances and candidates for anti-obesity.
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