Tri-substituted 8H-pyrido[2,3-D]pyrimidin-7-one compounds in treating CSBP/p38 kinase mediated diseases

摘要

A group of 2,4,8-trisubstituted-8H-pyrido[2,3- djpyrimidin-7-one compounds and processes for the preparation thereof is described. In particular a compound of the formula VII wherein R1 is an optionally substituted aryl or heteroaryl ring; and R3 is an optionally substituted aryl, or heteroaryl moiety; m is 0 or an integer having a value of I or 2; and Rg is a C1-4. alkyl. Also described is the use these compounds in treating CSBP/p38 kinase mediated diseases and pharmaceutical compositions for use in such therapy.