发明名称 |
MASS LABELS FOR BIOMOLECULES CONTAINING A 2,6-DIMETHYL-PIPERIDIN-l-YL METHYLENE OR A PYRIMIDIN-2-YL THIOMETHYLENE MASS MARKER MOIETY AND A SUCCINIMID-OXY-CARBONYL REACTIVE FUNCTIONAL GROUP |
摘要 |
A mass label for labelling and detecting a biological molecule by mass spectroscopy, which label comprises the following structure: X-L-M wherein X is a mass marker moiety comprising the following group: formula (I), wherein the cyclic unit is aromatic or aliphatic and comprises from 0-3 double bonds independently between any two adjacent atoms; each Z is independently N, N(R<SUP>1</SUP>), C(R<SUP>1</SUP>), CO, CO(R<SUP>1</SUP>), C(R<SUP>1</SUP>)<SUB>2</SUB>, O or S; X is N, C or C(R<SUP>1</SUP>); each R<SUP>1</SUP> is independently H, a substituted or unsubstituted straight or branched C<SUB>1</SUB>-C<SUB>6</SUB> alkyl group, a substituted or unsubstituted aliphatic cyclic group, a substituted or unsubstituted aromatic group or a substituted or unsubstituted heterocyclic group; and y is an integer from 0-10, L is a cleavable linker comprising an amide bond and M is a mass normalization moiety. |
申请公布号 |
WO2007012849(A3) |
申请公布日期 |
2007.03.29 |
申请号 |
WO2006GB02787 |
申请日期 |
2006.07.26 |
申请人 |
ELECTROPHORETICS LIMITED;HAMON, CHRISTIAN;SCHWARZ, JOSEF;BECKER, WOLFGANG;KIENLE, STEFAN;KUHN, KARSTEN;SCHAEFER, JUERGEN |
发明人 |
HAMON, CHRISTIAN;SCHWARZ, JOSEF;BECKER, WOLFGANG;KIENLE, STEFAN;KUHN, KARSTEN;SCHAEFER, JUERGEN |
分类号 |
G01N33/68;C07D207/40;C07D207/404;C07D207/46;C07D401/12;C07D403/12;C07K1/13;C07K5/078 |
主分类号 |
G01N33/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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