ENVIRONMENT-FRIEND PROCESS FOR THE SYNTHESIS OF QUATERNARY AMMONIO-STERO?DS

摘要

The invention relates to a new, environment-friend process for the synthesis of the known 4,4'-[3a,17ß-bis(acetoxy)-5a-androstane-2ß,l6ß-diyl]-bis(l,l-dimethyl-?i?erazinium) dibromide of formula (I) (from now on pipecuronium bromide) and l-[3a,17ß-bis(acetoxy)-2ß-(l-piperidinyl)-5a-androstane-16ß-yl]-l-methyl-piperidinium bromide of formula (II) (from now on vecuronium bromide). Furthermore the invention relates to the new intermediates of formula (III) and formula (IV) of the process, wherein the meaning of X is benzenesulfonate - in given case para-substituted with a methyl or a nitro group or a bromine atom - methanesulfonate, ethanesulfonate or trifluoromethanesulfonate ion.