摘要 |
The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R<1>,X, R<3>, x, and ring A are as defined in the present application. |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
GONZALES III, JESUS E;WILSON, DEAN MITCHELL;TERMIN, ANDREAS PETER;GROOTENHUIS, PETER DIEDERIK JAN;ZHANG, YULIAN;PETZOLDT, BENJAMAIN JOHN;FANNING, LEV TYLER DEWEY;NEUBERT, TIMOTHY DONALD;TUNG, ROGER D;MARTINBOUROUGH, ESTHER;ZIMMERMANN, NICOLE |