发明名称 |
SOLID FORMS OF THE MAGNESIUM SALT OF (S)-OMEPRAZOLE AND PROCESSES FOR THEIR PREPARATION |
摘要 |
New solid forms of the active ingredient magnesium salt of S-omeprazole, obtainable by a preparation process including: a) crystallizing a magnesium salt of S-omeprazole from a solution of a magnesium salt of S-omeprazole in a solvent system that includes a mixture of methanol/water with an amount of water equal to or greater than about 0.01 ml/g of the magnesium salt of S-omeprazole starting material; b) isolating the magnesium salt of S-omeprazole that appears in the prior operation; c) separating the free organic solvent from the magnesium salt of S-omeprazole obtained or, alternatively, separating both the free solvent and the solvation solvent. The new solid forms are obtained by a reproducible and robust process, with high yield and elevated optical purity, which is useful for the preparation of pharmaceutical products that contain said active ingredient. |
申请公布号 |
EP1765807(A1) |
申请公布日期 |
2007.03.28 |
申请号 |
EP20050760736 |
申请日期 |
2005.06.29 |
申请人 |
ESTEVE QUIMICA, S.A. |
发明人 |
BERENGUER MAIMO, RAMON;COPPI, LAURA;GASANZ GUILLEN, YOLANDA;MEDRANO RUPEREZ, JORGE |
分类号 |
C07D401/12;A61K31/4439;A61P1/04 |
主分类号 |
C07D401/12 |
代理机构 |
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