| 发明名称 |
Pyrrole and pyrazole derivatives as potentiators of glutamate receptors |
| 摘要 |
The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.
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| 申请公布号 |
US2007066573(A1) |
申请公布日期 |
2007.03.22 |
| 申请号 |
US20040570985 |
申请日期 |
2004.09.27 |
| 申请人 |
ALBAUGH PAMELA A;DOMINGUEZ-MANZANARES ESTEBAN;HONG JIAN E;HORNBACK WILLIAM J;JIANG DELU;ORNSTEIN PAUL L;THOMPSON MICHELLE L;TROMICZAK ERIC G;WU ZHIPEI;ZARRINMAYEH HAMIDEH;ZIMMERMAN DENNIS M;CASTANO MANSANET ANA M;HUFFMAN LARRY G;MILLER WILLIAM D |
发明人 |
ALBAUGH PAMELA A.;DOMINGUEZ-MANZANARES ESTEBAN;HONG JIAN E.;HORNBACK WILLIAM J.;JIANG DELU;ORNSTEIN PAUL L.;THOMPSON MICHELLE L.;TROMICZAK ERIC G.;WU ZHIPEI;ZARRINMAYEH HAMIDEH;ZIMMERMAN DENNIS M.;CASTANO MANSANET ANA M.;HUFFMAN LARRY G.;MILLER WILLIAM D. |
| 分类号 |
A61K31/675;A61K31/401;A61K31/4025;A61K31/415;A61K31/416;A61K31/4196;A61K31/42;A61K31/425;A61K31/433;C07D207/34;C07D207/36;C07D231/14;C07D401/10;C07D403/02;C07D403/04;C07D403/10;C07D405/02;C07D405/10;C07D409/10;C07D409/12;C07D413/02;C07D413/10;C07D417/02;C07D417/10 |
主分类号 |
A61K31/675 |
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