发明名称 |
Novel Dry Powder Inhalation System For Transpulmonary Administration |
摘要 |
The present invention provides a novel dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system of the present invention characterized by using a combination of: (1) a vessel housing a freeze-dried composition prepared by freeze-drying a composition liquid containing ingredients in a non-dissolved form, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.05 or more, and (iii) a property of becoming fine particles having a mean particle diameter (mass median aerodynamic diameter) of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) a device comprising a member capable of applying said air impact to the freeze-dried composition in said vessel, and a member for discharging the powder-form freeze-dried composition that has been made into fine particles. |
申请公布号 |
US2007065371(A2) |
申请公布日期 |
2007.03.22 |
申请号 |
US20050538837 |
申请日期 |
2005.06.13 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
YAMASHITA CHIKAMASA;AKAGI AKITSUNA;FUKUNAGA YUICHIRO |
分类号 |
A61K9/14;A61M15/00;A61J3/02;A61K9/00;A61K9/12;A61K9/19;A61K9/72;A61K38/28;A61K47/10;A61K47/12;A61K47/18;A61K47/20;A61K47/26;A61K47/40;A61L9/04;A61M;A61M13/00;A61P5/50;A61P43/00 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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