发明名称 |
FUSION PROTEINS CONTAINING RECOMBINANT CYTOTOXIC RNASES |
摘要 |
Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may be used in a variety of therapeutic methods for treating diseases or syndromes associated with unwanted or inappropriate cell proliferation or activation. |
申请公布号 |
EP1720996(A4) |
申请公布日期 |
2007.03.21 |
申请号 |
EP20050723127 |
申请日期 |
2005.02.14 |
申请人 |
IMMUNOMEDICS, INC. |
发明人 |
GOLDENBERG, DAVID M.;HANSEN, HANS J.;CHANG, CHIEN-HSING;VANAMA, SAILADJA;ROSSI, EDMUND A. |
分类号 |
C12N15/62;A61K38/46;A61K39/395;A61K47/48;A61K51/08;A61K51/10;C07K19/00;C12N9/22;C12P21/00;C12P21/02 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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