发明名称 |
Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and MR imaging techniques |
摘要 |
The invention provides for methods for producing water-soluble iron oxide nanoparticles comprising encapsulating the nanoparticles in phospholipids micelles. Also provided are methods for conjugating the inventive nanoparticles via functionalized phospholipids to a target molecule, such as an antibody. The invention further provides methods for using the nanoparticle-antibody conjugate of the invention as a contrast agent to image specific cells or proteins in a subject using fluorescent and magnetic imaging techniques.
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申请公布号 |
US2007059775(A1) |
申请公布日期 |
2007.03.15 |
申请号 |
US20060394040 |
申请日期 |
2006.03.29 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
HULTMAN KRISTI;WILLIS AMANDA;O'BRIEN STEPHEN;BROWN TRUMAN R.;HARRIS PAUL;TURRO NICHOLAS J.;GRZENDA ADRIENNE L. |
分类号 |
G01N33/567;G01N33/53;G01N33/551 |
主分类号 |
G01N33/567 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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