PLAD DOMAIN PEPTIDES WITH INCREASED SERUM HALF LIFE DUE TO CONJUGATION TO DOMAIN ANTIBODIES

摘要

Drug compositions, fusions and conjugates that contain a PLAD domain or functional variant of a PLAD domain are provided. The drug fusions and conjugates contain a PLAD domain or functional variant of PLAD domain that is fused or conjugated to an antigen-binding fragment of an antibody that binds serum albumin. The drug compositions, fusions and conjugates have a longer in vivo half-life in comparison with the unconjugated or unfused therapeutic or diagnostic agent.