PREPARATION OF FORM I OF CLOPIDOGREL HYDROCHLORIDE

摘要

The present invention relates to a process for preparation of crystalline Form I of clopidogrel hydrochloride comprising dissolving clopidogrel free base in one or more solvents selected from 1,2-dimethoxyethane, dimethoxy methane, methoxy ethoxyethane, methoxy propoxymethane or mixtures thereof, adding hydrogen chloride to the mixture and isolating crystalline Form I of clopidogrel hydrochloride.