发明名称 |
Glucocorticoid modulation of nucleic acid-mediated immune stimulation |
摘要 |
The present invention provides methods for minimizing or inhibiting immune responses to immunostimulatory nucleic acids by pretreating with one or more doses of a glucocorticoid prior to nucleic acid administration. The nucleic acids are typically administered using a lipid-based carrier system such as a nucleic acid-lipid particle or liposome. As a result, patients following a glucocorticoid dosing regimen advantageously benefit from nucleic acid therapy without suffering any of the immunostimulatory side-effects associated with such therapy.
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申请公布号 |
US2007054873(A1) |
申请公布日期 |
2007.03.08 |
申请号 |
US20060511855 |
申请日期 |
2006.08.28 |
申请人 |
PROTIVA BIOTHERAPEUTICS, INC. |
发明人 |
MACLACHLAN IAN;JUDGE ADAM |
分类号 |
A61K48/00;A61K31/573 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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