发明名称 |
PEPTIDES THAT SELECTIVELY HOME TO HEART VASCULATURE AND RELATED CONJUGATES AND METHODS |
摘要 |
The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treating any of a variety of cardiovascular diseases as described below. Thus, the present invention provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CRPPR (SEQ ID NO: 1) or a peptidomimetic thereof. The invention further provides an isolated peptide or peptidomimetic which has a length of less than 60 residues and includes the amino acid sequence CARPAR (SEQ ID NO: 5) or a peptidomimetic thereof, or amino acid sequence CPKRPR (SEQ ID NO: 6) or a peptidomimetic thereof. |
申请公布号 |
WO2006029343(A3) |
申请公布日期 |
2007.03.01 |
申请号 |
WO2005US32205 |
申请日期 |
2005.09.07 |
申请人 |
THE BURNHAM INSTITUTE;ZHANG, LIANGLIN;HOFFMAN, JASON, A.;RUOSLAHTI, ERKKI |
发明人 |
ZHANG, LIANGLIN;HOFFMAN, JASON, A.;RUOSLAHTI, ERKKI |
分类号 |
A61K38/00;C07K7/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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