CLEAVAGE OF ANTIFOLATE COMPOUNDS

摘要

A method of combating toxicity caused by an antifolate compound of Formula I , in an individual who has been administered the compound. The method comprise s administering an enzyme that has carboxypeptidase G activity to the individual. A method of cleaving a compound comprising a structural fragment of Formula IV, the method comprising contacting the compound comprising the structural fragment of Formula IV with an enzyme that has carboxypeptidase G activity.