QUANTITATIVE ASSAYS FOR PDGFR-ß IN BODY FLUIDS

摘要

The present invention is directed to the detection and quantification of total PDGFR-ß in body fluids, particularly serial changes of total PDGFR-ß levels in a subject's body fluids. Further, the invention is directed to detecting and quantitatiing total PDGFR-ß in conjunction with one or more other proteins, such as, oncoproteins, angiogenic factors, tumor markers, inhibitors, growth factor receptors, metastasis proteins, and tumor suppressors. The disclosed methods are diagnostic/prognostic for diseases, and useful to select therapies for patients with diseases, preferably preneoplastic/neoplastic diseases. The disclosed methods are particularly useful to monitor the status of a patient's disease, and/or to monitor how a patient is responding to a therapy.