ENGINEERED ANTIBODIES WITH NEW WORLD PRIMATE FRAMEWORK REGIONS

摘要

The present invention provides an antibody or antigen-binding portion thereo f having a variable region comprising at least two complementarity determining regions (CDRs) and at least three framework regions. The the framework regio ns are, or are derived from New World primate framework regions, and at least o ne of the CDRs is a non-New World primate CDR.