PROCESS FOR PRODUCING CARBAPENEM DERIVATIVES THROUGH REACTIONS WITHOUT ISOLATING INTERMEDIATES

摘要

An industrially advantageous process for the production of carbapenem derivatives, namely, a process for the production of compounds (V), solvates thereof, or crystals of the solvates, characterized by comprising the first step of reacting a compound (I) with a metal catalyst in a solvent to form a compound (II), the second step of mixing the compound (II) containing reaction fluid obtained in the first step with diphenylphosphochloridate and a base to form a compound (III), and the third step of mixing the compound (III) containing reaction fluid obtained in the second step with a compound (IV) or a salt thereof to form a compound (V): wherein R¹ is a carboxyl-protecting group; R² is hydrogen or a hydroxyl-protecting group; and R³ is hydrogen or an amino -protecting group, with the proviso that neither compound (II) nor compound (III) is isolated.