GENE THERAPEUTIC AGENT OF CANCER COMPRISING RECOMBINANT ADENO-ASSOCIATED VIRUS CONTAINING ANTISENSE CDNAS OF VEGF-A, VEGF-B AND VEGF-C AND RECOMBINANT ADENO-ASSOCIATED VIRUS CONTAINING VEGFR TRUNCATED SOLUBLE CDNA

摘要

The present invention relates to a gene therapeutic agent for cancer, comprising a recombinant adeno-associated virus containing the antisense cDNAs of VEGF-A, VEGF-B and VEGF-C and a recombinant adeno- associated virus containing the truncated soluble cDNA of VEGFR. The gene therapeutic agent according to the invention reduces the growth of tumors by inhibiting the expression and function of VEGF involved in angiogenesis necessary for the proliferation and metastasis of tumors. Thus, the gene therapeutic agent can be effectively used to treat cancer at a gene level.