PYRIDYLPHENOL COMPOUND AND USE THEREOF

摘要

Discloses is a compound which has a metastin receptor antagonistic activity and is useful for the prevention/treatment of hormone-dependent cancer, benign prostatomegaly, endometriosis, precocious puberty, hysteromyoma or the like. A compound represented by the formula below or a salt or prodrug thereof; and a pharmaceutical comprising the compound, salt or prodrug. [Chemical formula] wherein the ring A represents a 5- to 8-membered homocyclic or heterocyclic ring which may further have a substituent other than the group: -X-R<SUP>1</SUP> where X represents a bond or a spacer and R<SUP>1</SUP> represents an amino group which may have a substituent or a nitrogenated heterocyclic ring group which may have a substituent; the ring B represents a benzene ring which may have a substituent; R<SUP>2</SUP> represents a homocyclic or heterocyclic ring group which may have a substituent; and R<SUP>3</SUP> and R<SUP>4</SUP> independently represent a hydrogen atom, a cyano group, an acyl group or a hydrocarbon group which may have a substituent.