发明名称 |
METHODS FOR CONSTRUCTION AND SCREENING OF LIBRARIES OF CHEMOKINE VARIANTS |
摘要 |
<p>The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.</p> |
申请公布号 |
EP1423423(B1) |
申请公布日期 |
2007.02.14 |
申请号 |
EP20020777276 |
申请日期 |
2002.09.05 |
申请人 |
UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI) |
发明人 |
GOROCHOV, GUY;HARTLEY, OLIVER;DORGHAM, KARIM;DEBRE, PATRICE;OFFORD, ROBIN |
分类号 |
C07K14/52;A61K38/00;A61K38/04;C12N1/21;C12N15/10;C40B40/02 |
主分类号 |
C07K14/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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