发明名称 |
Novel nitrophenyl mustard and nitrophenylaziridine alcohols and their corresponding phosphates and their use as targeted cytotoxic agents |
摘要 |
The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzymeprodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.
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申请公布号 |
US2007032455(A1) |
申请公布日期 |
2007.02.08 |
申请号 |
US20060577078 |
申请日期 |
2006.07.13 |
申请人 |
DENNY WILLIAM A;ATWELL GRAHAM J;YANG SHANGJIN;WILSON WILLIAM R;PATTERSON ADAM V;HELSBY NUALA A |
发明人 |
DENNY WILLIAM A.;ATWELL GRAHAM J.;YANG SHANGJIN;WILSON WILLIAM R.;PATTERSON ADAM V.;HELSBY NUALA A. |
分类号 |
A61K31/675;A61K31/66;C07C237/32;C07C309/66;C07C317/48;C07D203/14;C07F9/02;C07F9/09 |
主分类号 |
A61K31/675 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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