DERMORPHIN ANALOGS WITH ANALGESIC ACTIVITY

摘要

New opioid heptapeptide analogs of dermorphin characterised by the fact that, like dermorphin, they maintain a tyrosine residue in position 1 and a D-a-aminoacid, preferably D-Ala, in position 2, and by the fact that in position 7 they have the aminoacid of maximum basicity, i.e. arginine. The preferred peptide of the invention, Arg⁷-dermorphin, referred to as arginorphin, has a potent analgesic activity. This activity largely comes about at the peripheral opiod nociceptor level, without involving the more serious central side effects typical of opiates.