Super-antigens derived from the SARS coronavirus E2 spike protein

摘要

The present invention relates to a super-antigen fusion protein, comprising: a peptide fragment derived from SARS E2 spike protein; and a translocating peptide fragment for transporting a protein into a cell and translocating the protein in cytosol; wherein, the SARS E2 spike protein fragments locate between the amino acid position 692 and 1050 of the viral protein. The present invention further relates to DNA sequences encoding the SARS E2 spike protein fragments and fusion protein thereof; wherein the DNA sequences are able to express the proteins in an E. Coli expression system. The preferred translocating peptide is obtained from Pseudomonas exotoxin.