Dosage form with pH-independent sustained release for active substances with pH-dependent solubility

摘要

Medicament formulations (A) for retarded, pH-independent drug release, comprise (a) layer(s) of water-insoluble polymer(s) (I), (b) layer(s) of pH dependent water-soluble polymer(s) (II) and (c) a core containing a drug (III) with strongly pH-dependent water solubility, the core (c) additionally contains osmagent(s) (IV).