COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATION AND STROKE
摘要
<p>Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP inhibition. Therapeutic applications are relevant for preventing or inhibiting neurological cell death for a variety of neurodegenerative conditions including Parkinson's disease, ischemia, and stroke. Also disclosed is a high-throughput screen for identifying compounds capable of inhibiting PARG and/or PARP.</p>
申请公布号
WO2007014226(A2)
申请公布日期
2007.02.01
申请号
WO2006US28894
申请日期
2006.07.26
申请人
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;HERGENROTHER, PAUL, J.;PUTT, KARSON, S.;LIU, XIANJUN